涓€绉嶉偦鑻簩鐢查啗娑堟瘨鍓傜殑姣掔悊瀛︾爺绌
鍙戝竷鏃堕棿锛
2022-11-02
涓€ 绉嶉偦鑻簩 鐢查啗娑堟瘨鍓 (CidexOPA )涓轰复搴婃秷 姣掔敤楂樻按骞虫秷姣掑墏 锛岀洰鍓嶄富瑕 搴旂敤浜庡尰鐤楀櫒姊版蹈娉 娑堟瘨 锛岀壒鍒槸鍐呴暅娑堟瘨銆備笌鐜伴噰鐢 鐨勫叾浠栨秷姣掑墏鐩 姣旓紝鍏跺叿鏈夋潃鑿岃氨骞匡紝浣跨敤娴撳害浣庯紝鏉€鑿屾椂闂寸煭锛屽埡婵€ 鎬у皬 锛岃厫铓€鎬т綆绛夌壒鐐 锛屽湪涓村簥閫愭笎骞挎硾搴旂敤銆傛湰瀹 楠岄€氳繃妫€娴嬪叾瀵瑰皬榧犳€ユ€х粡 鍙f瘨鎬у拰楠ㄩ珦鍡滃鏌撶孩 缁嗚優寰牳褰㈡垚鐨勫奖鍝 锛屽苟涓庡父鐢ㄥ唴闀滄秷姣掑墏鎴婁簩閱 杩涜 姣旇緝 锛屼互璇勪环鍏朵复搴婂簲鐢ㄥ畨鍏ㄦ€с€ 1 鏉愭枡涓庢柟娉 1锛? 鏉愭枡 CidexOPA楂樻按骞虫秷姣掑墏 (寮虹敓鍏 鍙?涓昏鎴愬垎 涓洪偦鑻簩 鐢查啗 (ortho—phthalaldehyde锛孫PA)鐨勬贰钃 鑹查€忔槑娑蹭綋 锛屾 涓€閭 鑻簩 鐢查啗鍚噺 涓 5500mg锛廘锛 pH7锛?5銆侷CR灏 榧燵璁 鍙瘉鍙 SCXK(J)2007— 0003]锛岃喘浜庡悏鏋楀ぇ瀛 鐧芥眰鎭╁尰瀛 闄㈠疄楠屽姩鐗 涓績 锛 鍔ㄧ墿楗 鍏诲湪 鏅€ 绾 鍔ㄧ墿鎴 锛屾俯 搴 22~C锛岀浉 瀵 婀垮害 50锛 銆 1锛? 鏂 娉 1锛?锛? 灏 榧犳€ユ€х粡 鍙f瘨鎬ц瘯楠 閫夊彇 18锝?2g灏 鐧介紶5O鍙紝闅忔満鍒 5缁 锛屾瘡缁勯泴闆勫悇鍗 锛岃瘯楠屽墠绂侀8h锛屼笉绂佹按 銆傜粰浜 CidexOPA鍘熸恫鍓傞噺鍒嗗埆涓 4锛?銆 5锛?銆?锛?銆?锛?鍜 6锛?g锛弅g(浣撻噸 )锛屾寜 0锛?mL锛弆Og涓€ 娆℃€х亴 鑳冪粰鑽€傜粰鑽悗姝e父楗插吇锛岃繛缁瀵 14d锛岃 瀵熷苟姣旇緝鍚勭粍灏 榧犱腑姣掕〃鐜板強姝讳骸鎯呭喌銆 1锛?锛? 灏忛紶楠ㄩ珦鍡滃鏌撶孩缁嗚優寰牳璇曢獙 閫夊彇 25 — 30g灏 榧?0鍙紝闅忔満鍒嗘垚 6缁 锛屾瘡缁勯泴闆勫悇鍗 锛屽疄 楠屽墠绂侀 4h锛屼笉绂佹按 銆侰idexOPA瀹為獙缁 鍓傞噺 涓 500銆?000鍜?000mg锛弅g(浣撻噸 )锛岄槼鎬у鐓х粍 缁欎簣 鐜7閰拌兒 40mg锛弅g(浣撻噸)锛岄槾鎬у鐓х粍缁欎簣绛夐噺钂 棣忔按 鐏 鑳冦€傛垔 浜 閱 缁 缁欎簣 20 L鎴 浜 閱 5000 mg锛弅g(浣撻噸)銆傞噰鐢ㄧ粡 鍙g亴 鑳 30h鏌撴瘨娉 锛屽嵆棣栨 鏌撴瘨鍚 24h鍐嶇粰鑽 1娆 锛岀 2娆$粰鑽悗 6h灏嗗姩鐗 棰堟鑴辨澶勬 锛屽皬鐗涜娓呭啿娲楄偂楠ㄩ楂撹厰 锛屽彇楠ㄩ珦鍐 娲楁恫娑 鐗 锛岀敳閱 鍥哄畾 Giemsa鏌撹壊 鍚庢樉寰暅涓嬭 鏁 1000涓楂 鍡滃鏌撶孩缁嗚優 (PCE)涓墍鍚井 鏍哥粏鑳 鏁般€傚苟瑙傚療 姝e父绾㈢粏 鑳炴暟 (NCE)锛岃绠 PCE锛廚CE 鐨勬瘮鍊笺€傚疄楠岃繃绋 涓瀵熷苟 姣旇緝鍚勭粍灏 榧犺繘椋 銆佹椿 鍔ㄦ鏁 锛岀簿绁炵姸鎬併€ 2 缁撴灉 2锛? 灏忛紶鎬ユ€х粡 鍙f瘨鎬ц瘯楠岀粨鏋淐idexOPA鎸夌粰鑽 鍓傞噺瀵瑰皬 榧犵亴 鑳冿紝鍚 鍓傞噺缁 灏 榧犲潎鏃犱笉 鑹〃鐜 锛岃瀵 14d锛岃繃绋 涓悇缁勫皬 榧犺姣 鍏夋辰 锛岄ギ椋熴€佹椿鍔ㄦ甯 锛岀簿绁炵姸鎬佷匠 锛屼綋閲嶆棤鍑忚交 锛屽叏 绋嬫湭瑙佸皬 榧犳 浜°€傚皬 榧犲崐鏁拌嚧姝婚噺 >6500mg锛弅g 浣撻噸銆 2锛? 灏忛紶楠ㄩ珦鍡 澶氭煋绾㈢粏鑳炲井鏍歌瘯楠岀粨鏋 灏忛紶楠ㄩ珦鍡滃鏌撶孩 缁嗚優寰 鏍哥巼瑙佽〃 1锛屽寰牳 鐜?‰)缁忓钩鏂规牴杞崲锛岃繘琛屾柟宸垎鏋愶紝CidexOPA鍚 鍓傞噺缁勫皬 榧犲棞澶氭煋绾㈢粏鑳炲井鏍哥巼涓庨槾鎬у鐓х粍鏃犳樉 钁楁€у樊寮 (P>0锛?5)锛孋idexOPA缁勪笌鎴婁簩閱涚粍灏 榧 鍡滃鏌 绾 缁 鑳 寰 鏍 鐜 姣 杈 宸 寮 鏃 鏄 钁 鎬 (P > O锛?5)锛岄槼鎬у鐓х粍涓庨槾鎬у鐓х粍姣旇緝宸紓鏈夋樉钁 鎬 (P<0锛?1)锛岀粨鏋滆〃鏄 锛屼笁缁勫墏閲 CidexOPA鍧囦笉 浼 寮曡捣灏 榧犻楂 鍡 澶氭煋 绾㈢粏鑳 寰 鏍稿彂 鐢熺巼澧 鍔犮€ PCE锛廚CE姣旂巼鍧囧ぇ浜 0锛?锛岃瘉 鏄庡悇缁勮瘯楠屽墏閲忓楠 楂撴棤 鏄庢樉鎶戝埗浣滅敤 锛屽疄楠屽墏閲 鐨 CidexOPA瀵瑰皬 榧 楠ㄩ珦鍡滃鏌撶孩缁嗚優鏌撹壊浣撴病鏈夋崯瀹充綔鐢ㄣ€傚疄楠岃繃绋 涓紝CidexOPA鍚勭粍灏 榧犺姣涘厜娉 锛岄ギ椋 銆佹椿鍔ㄦ甯 锛 绮剧浣 銆傛垔浜岄啗缁勫皬榧犺姣涘厜娉 锛岄ギ椋熸甯 锛屾椿鍔ㄩ 鐜囧噺浣 锛岀簿绁炲皻鍙€傜幆纾烽叞鑳虹粍灏忛紶琚瘺鏃犲厜娉 锛岄ギ 椋 灏氬彲 锛屾椿鍔ㄩ鐜囧強鑼冨洿鏄庢樉闄嶄綆 锛岀簿绁炲樊銆侟/p>
3 璁 璁 1994骞 CidexOPA鍦ㄥ姞 鎷垮ぇ棣栨搴旂敤浜 鍐呴暅 娑堟瘨锛?999骞翠綔涓烘柊鍨嬮珮鏁堝寲瀛︽秷姣掑墏閫氳繃 FDA 璁よ瘉 锛屽叾閫 杩 浜よ仈 銆佷汉鑶 绛夋満 鍒 杈惧埌 娑堟瘨 鐏 鑿屼綔 鐢?uml;]銆傛牴鎹崼鐢熼儴棰 甯冪殑 2002骞寸増銆婃秷姣掓妧鏈 鑼冦€嬪寲瀛︾墿璐ㄦ€ユ€ф瘨鎬у垎绾ф爣鍑嗚瘎浠疯瀹氾紝LD銆?gt; 5000mg锛弅g(浣撻噸)鑰呭睘瀹為檯鏃犳瘨 锛屾湰 瀹為獙璇 鏄 ci— dexOPA灞炲疄闄呮棤姣掔骇 銆 鏈疄楠屽悇鍓傞噺缁勫灏忛紶楠ㄩ珦鍡滃鏌撶孩缁嗚優鏌撹壊 浣撴病鏈夋崯 瀹充綔鐢 锛岃瘉瀹炲湪鏈疄楠屾潯浠朵笅 CidexOPA 涓嶅瓨鍦ㄨ嚧绐佸彉浣滅敤銆侰idexOPA缁勮瀵 PCE涓庢垔浜 閱涚浉 姣旇櫧鏃犲樊寮 锛屼絾鎴婁簩閱涙湰韬叿鏈夊唴鍦ㄦ瘨鎬 锛屽鍖 鍔′汉鍛樺強鎮h€呭叿鏈夋綔鍦ㄥ仴搴峰嵄瀹炽€傚湪瀹為檯鍐呴暅娲楁秷 涓紝鎴婁簩閱涗负杈惧埌娑堟瘨鏍囧噯 锛岄渶瑕佽緝闀挎椂闂存蹈娉°€備緥 濡 锛?100mg,锛廘鐨 OPA浣滅敤浜庢薄鏌撶殑 10銆俢fu锛弇l鐗 鍒嗘敮鏉嗚弻鐨勫钩鍧囨潃鐏椂闂翠负 6min锛岃€ 1锛?锛呯殑鎴婁簩 閱涢渶瑕 30min J銆侰idexOPA浣滀负涓€绉嶉珮鏁 锛岀粡娴庯紝 瀹夊叏鐨勬柊鍨嬫秷姣掑墏 ]锛屽叿鏈夊緢楂樼殑涓村簥搴旂敤浠峰€笺€ 鍙 鑰 鏂 鐚 [1] 闄堣弫 锛岃 鑳介攱锛庨偦 鑻簩 鐢查啗娑堟瘨 浣滅敤 鍙婂叾鏈 鍒 [J]锛庡浗澶 鍖诲 (娴佽鐥呭浼犳煋鐥呭鍒嗗唽 )锛?004锛?1(2)锛?21—124锛 (23 鏉庡叚浜 锛庝竴绉嶆柊 鐨勫寲瀛︾伃鑿屽墏 涓€閭昏嫰 浜 鐢查啗 [J]锛庝腑鍗庡尰闄㈡劅 鏌撳 鏉傚織锛?003锛?3(4)锛?97—398锛 [3] 鏉 闃 锛屽垬鏋 锛岀敯鍗 鏂囷紟鏈烘礂 娑堟瘨 鏉′欢涓 閭昏嫰浜 鐢查啗鍜屾垔 浜岄啗鑰 鐢ㄦ€ 姣旇緝鍙婂叾缁 娴庡璇 浠 [J]锛庝腑鍗庢秷 鍖 鍐呴暅 鏉傚織 锛?010锛?7 (2)锛?7—79锛嶞/p>
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